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The 2019 APN Symposium
First Asian Pharmacometrics Network (APN) Symposium, November 2019
Bangkok Narai Hotel, Thailand

< 19th November >

Time Topic Speaker
08:15 - 08:45 am Registration -
08:45 - 09:00 am Opening Remark Suvatna Chulavatnatol, Mahidol University, Thailand
09:00 - 10:00 am Plenary Lecture 1:
Asian Pharmacometrics Network: Historical background and objectives
Kyungsoo Park, Yonsei University, Korea
10:00 - 10:30 am Refreshment Break 1 & Poster
10:30 - 11:00 am Population PK/PD for antimalarial treatment
Joel Tarning, Mahidol University, Thailand
11:00 - 11:30 am Pharmacometrics in the Development of Ixekizumab Laiyi Chua, Lilly, Singapore
11:30 - 12:00 am Pharmacokinetic/Pharmacodynamic-Drug Development Ariya Khumvichai, Medica Innova Co., Ltd, Thailand
12:00 - 13:00 pm Lunch & Poster
13:00 - 13:30 pm Physiologically based pharmacokinetic model application Manupat Lohitnavy, Naresuan University, Thailand
13:30 - 14:00 pm Modeling and Simulation Technique for Clinical Development of New Drugs Takahiko Tanigawa, Bayer, Japan
14:00 - 14:30 pm Bayesian Dose-Finding Phase I Trial Design Incorporating Pharmacokinetic Assessment in the Field of Oncology Kanji Komatsu, Astellas, Japan
14:30 - 15:00 pm Refreshment Break 2 & Poster
15:00 - 15:30 pm Pharmacometrics and Modeling for Biologics Wararat Limothai, Government Pharmaceutical Organization (GPO), Thailand
15:30 - 16:00 pm Population Pharmacokinetics Followed by Virtual Bioequivalence Trials Uthpali Mannapperuma, University of Colombo, Sri Lanka
16:00 - 16:30 pm Warfarin population pharmacokinetics study in patients with renal impairment Yu-Shen Yang, National Taiwan University, Taiwan


< 20th November >

Time Topic Speaker
08:30 - 09:00 am Registration -
09:00 - 10:00 am Plenary Lecture 2:Physiologically Based Pharmacokinetic (PBPK)
Modeling-An Important Tool in the Drug Development Toolkit
Vikram Arya, FDA, USA.
10:00 - 10:30 am Refreshment Break 1 & Poster
10:30 -11:00 am Clinical pharmacometrics in real world data Dongwoo Chae, Yonsei University, Korea
11:00 - 11:30 am Development of Single and Repeated Time-to-Event Model using
Parametric Approach
Sabariah Noor Harun, Universiti Sains Malaysia, Malaysia
11:30 - 12:00 pm Mechanistic PKPD Modelling of Primaquine Palang Chotsiri, Mahidol University, Thailand
12:00 - 13:00 pm Lunch & Poster
13:00 - 14:00 pm Plenary Lecture 3:Prioritizing Drug Candidates in Precision Oncology for Rare Cancer:
A Case Study in Thai Liver Fluke-Associated Cholangiocarcinoma
Somponnat Sampattavanich, Mahidol University, Thailand
14:00 - 14:30 pm Voriconazole Population Pharmacokinetic Study Shu-Wen (Wendy) Lin, National Taiwan University, Taiwan
14:30 - 15:00 pm Refreshment Break 2 & Poster
15:00 - 15:00 pm Adequacy of Isoniazid and Rifampicin in Anti-Tuberculosis Treatment in Children; A Pharmacometric Approach Blessed Winston Aruldhas,
Christian Medical College, India
15:30 - 16:00 pm Applications of PBPK Modeling in Pediatric Drug Development Rama Sivasubramanian,
Novartis Healthcare Pvt. Ltd., India
16:00 - 16:30 pm Pharmacometrics and Pharmacokinetics in Nepal Bimal Kunwar,
Nobel College of Health Science, Nepal
16:30 - 17:00 pm Closing ceremony Kyungsoo Park,
Yonsei University, Korea


The 2019 APN Satellite Workshop
The First Asian Pharmacometric Network (APN) Symposium (Workshop)
On 18th November 2019 Computer Laboratory Room, 7th Floor, Ratcharat Building, Faculty of Pharmacy, Mahidol University
Time Topic Speaker
08:15 - 08:45 Registration -
08:45 - 09:00 Opening Remark Assoc. Prof. Dr. Suvatna Chulavatnatol
Dean Faculty of Pharmacy, Mahidol University, Thailand
09:00 - 09:40 Introduction to QSP Mr. Hyeonsoo PARK
Department of Pharmacology, Yonsei University College of Medicine, South Korea
09:40 - 10:30 Introduction to MALTAB/Simbiology Dr. Wooyul LEE, Department of Pharmacology, Yonsei University College of Medicine, South Korea
10:30 - 10:45 Coffee Break 1
10:45 - 11:25 Pharmacometrician’s gateway to QSP: TMDD model Prof. Dr. Dongwoo Chae, Department of Pharmacology, Yonsei University College of Medicine, South Korea
11:25 - 12:15 Introduction to QSP experiments Assist. Prof. Dr. Jungho LEE, Department of Pharmacology, Eulji University, South Korea
12:15 - 13:15 Lunch
13:15 -14:05 Cell cycle models: Goldbeter and Novak-Tyson models Prof. Dr. Dongwoo Chae, Department of Pharmacology, Yonsei University College of Medicine, South Korea
14:05 - 14:45 Modeling the RTK-MAPK pathway Prof. Dr. Dongwoo Chae, Department of Pharmacology, Yonsei University College of Medicine, South Korea
14:45 - 15:00 Coffee Break 2
15:00 - 17:00 Physiologically Based Pharmacokinetic (PBPK) workshop 1. Assoc. Prof. Dr. Manupat Lohitnavy, Naresuan University, Phitsanulok, Thailand
2. Ms. Kimheang Ya, Naresuan University, Phitsanulok, Thailand
3. Assoc. Prof. Dr. Korbtham Sathirakul, Mahidol University, Bangkok, Thailand
4. Asst. Prof. Dr. Wichit Nosoongnoen Mahidol University, Bangkok, Thailand
5. Dr. Pattarawit Rukthong, Srinakharinwirot University, Nakhon Nayok, Thailand
6. Dr. Uthpali Mannapperuma, University of Colombo, Colombo, Sri Lanka
17:00 - 17:15 Closing speech 1. Prof. Dr. Dongwoo Chae, Department of Pharmacology, Yonsei University College of Medicine, South Korea
2. Assoc. Prof. Dr. Manupat Lohitnavy, Naresuan University, Phitsanulok, Thailand
3. Assoc. Prof. Dr. Korbtham Sathirakul, Mahidol University, Bangkok, Thailand


The 2020 APN Symposium
2020 Asian Pharmacometrics Network (APN) Symposium
18-19th November (Virtual)


< 18th November >

Time* Topic Speaker
07:00 - 07:15 Registration  
07:15 - 07:30 Opening Remark Surulivelrajan Mallayasamy
07:30 - 08:20 Plenary Lecture 1 Chair: Surulivelrajan Mallayasamy
  Using pharmacometrics to explore
pharmacokinetic and pharmacodynamic
relationship in a pediatric setting
Richard Brundage, University
of Minnesota, USA
08:20 - 08:30 Break
08:30 - 09:45 Academic Research 1
Chairs: Lai-San Tham, Korbtham Sathirakul
  Physiologically-Based Pharmacokinetic Modelling
of Complex Drug-Drug-Disease Interactions: A
Case Study of Rivaroxaban
Eric Chun Yong Chan,
National University of
Singapore
  Modeling adherence using
pharmcometric approaches
Surulivelrajan Mallayasamy,
Manipal Academy of Higher
Education, India
  Population pharmacokinetic modeling to optimize
dosage regimens of antiretroviral (ARV) drugs in
Thai HIV-infected patients
Baralee Punyawudho,
Chiang Mai University,
Thailand
09:45 - 10:10 Break
10:10 - 11:50 Clinical Research
Chairs: Kyungsoo Park, Surulivelrajan Mallayasamy
  Dynamic predictive model for postoperative
nausea and vomiting for intravenous fentanyl
patient-controlled analgesia
Dongwoo Chae, Yonsei
University, Korea
  Application of Pharmacometrics in Clinics Vijay Ivaturi, University of
Maryland, USA
  Utility of population pharmacokinetic model developed
from phase I study data for the further drug development
Jaeseong Oh, Seoul National University, Korea
  Use of pharmacometrics approaches to interpret therapeutic drug
monitoring data on lithium in SriLankan patients
Uthpali Mannapperuma, University of Colombo, Sri Lanka
11:50 - 12:30 Break
12:30 - 13:20 Plenary Lecture 2 Chair: Atsunori Kaibara
  Over Twenty Years Contribution in Educating Pharmacometrics for Japan Industry Takahiko Tanigawa, Bayer, Japan
13:20 - 13:45 Break
13:45 - 14:45 Student Session 1 Chairs: Yoke-Lin Lo
Yunn - Fang Ho
A pharmacometric time-to-event modeling for
death among Asian patients with symptomatic COVID-19
Orwa Albitar, Universiti Sains,Malaysia
Prediction of concentration of 5-fluorouracil (5-FU) in plasma and bone
marrow by a physiologically based pharmacokinetic model after IV bolus and
continuous infusion regimens
Chih-Jia Chao, National Taiwan University, Taiwan
Association of cigarette smoking with plasma concentration
of Efavirenz among HIV positive patients
Chow Ngah Kuan, Universiti Sains, Malaysia
Application of PBPK model for Caffine in
clinically non-responsive neonates in the
treatment of Apnoea of prematurity
Sahiti Thotakura, Manipal Academy of Higher Education, India
14:45-14:50 Closure of Day 1 Surulivelrajan Mallayasamy


< 19th November >

Time Topic Speaker
07:30 - 08:20 Plenary Lecture 3 Chair: Kyungsoo Park
  Predictive Health Analytics: Next big Thing Joga Gobburu, University of
Maryland, USA.
08:20 - 08:30 Break
08:20 - 08:30 Academic Research 2 Chairs: Lai-San Tham, Korbtham Sathirakul
  Population Pharmacokinetics of Levofloxacin After
Oral Administration in Healthy Indonesian Volunteers
Akhmad Kharis Nugroho,
Universitas Gadjah Mada
Yogyakarta, Indonesia
  Repurposing Drugs for COVID-19: An approach for
treatment in the Pandemic
Sitaram Khadka, Shree
Birendra Hospital, Nepal
  Application of population pharmacokinetic
approach in oncology
Vikram Gota, ACTREC, India
  PK/PD simulation-based evaluation of recommended penicillin G dosage regimen
for Streptococcus spp. infective endocarditis patients
Chotirat Nakaranurack, Chulalongkorn University, Thailand
10:10 - 10:35 Break
10:35 - 12:15 Industry/New innovations Chairs: Rama Sivasubramanian, Atsunori Kaibara
  Accelerated quantitative pharmacology analysis
with Pharmaceutical Modeling and Simulation(PUMAS)
Vijay Ivaturi, University of Maryland, USA
  Current and Future Perspective of Model Informed Drug Development in Japan So Miyoshi, Pfizer, Japan
  Nanomedicines: PBB modelling techniques and IVIVIC Matthias Gerhard Wacker, National University of Singapore
  Application of Pharmacometrics in Drug-Drug interaction
studies and dosage prediction
Ramachandra Sanghana, Novartis, India
12:15 - 13:00 Break
13:00 - 14:00 Student Session 2 Chairs: Surulivelrajan Mallayasamy, Korbtham Sathirakul
  Dose optimzation of Aminophylline in preterm neonates
(32 weeks of Gestational Age) based on population pharmacokinetic modeling approach
Shivakumar, Manipal Academy of Higher Education, India
  Preliminary results: Influence of genetic and non-genetic factors
on donepezil concentrations in Thai patients with Alzheimer's disease
using population pharmacokinetic modelling approach
Thitipon Yaowaluk, Mahidol University, Thailand
  Population pharmacokinetics of Levitiracetam in Indian epileptic patients Jeffrey Raj, KEM Hospital, India
  Impact of Albumin and Omeprazole on Steady-State Population Pharmacokinetics
of Voriconazole and Development of a Voriconazole Dosing Optimization Model
in Thai Patients with Hematologic Diseases
Buddharat Khan-asa, Mahidol Unviersity, Thailand
14:00 - 14:15 Closing Remark Kyungsoo Park
* Indian Standard Time

The 2020 APN Satellite Workshop
PUMAS Pharmacometrics Workshop using Julia Hub
20th November (Virtual)
Lead instructor: Dr. Vijay Ivaturi, University of Maryland School of Pharmacy, MD, USA
Instructors: Dr. Vijay Ivaturi & Team
Time* Topic
08:00 – 08:15 Introductions and agenda
08:15 – 09:00 Introduction to Julia and Pumas
09:00 – 10:00 Model based simulations - Demo and Work-along
10:00 – 10:15 Break
10:15 – 11:15 Simulations – hands-on
11:15 – 12:15 Non-compartmental analysis
12:15 – 12:30 Break
12:30 – 13:30 Non-linear mixed effects model fitting
13:30 – 14:00 Wrap-up
* Indian Standard Time

The 2021 APN Workshop
Basic Pharmacometrics Workshop using Monolix
Thursday, 3 June 2021 (Virtual)
Dr. Akhmad Kharis Nugroho, Universitas Gadjah Mada, Indonesia
Dr. Géraldine Ayral, Lixoft Inc., France
Time(Jakarta time, GMT +7) Agenda
09:00 – 09:15 Opening ceremony
Prof. Dr. apt. Agung Endro Nugroho, M.Si.
Dean Faculty of Pharmacy Universitas Gadjah Mada
09:15 – 10:15 Keynote Speech: Pharmacometrics: Whether it has
arrived to deliver for all the stakeholders?

M.Surulivel Rajan M.Pharm, PhD
Manipal College of Pharmaceutical Sciences, Manipal, India
10:15 – 12.:00 Workshop part A: Data preparation and Basic Monolix operation
Prof. Dr. apt. Akhmad Kharis Nugroho, M.Si.
Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta, Indonesia
12:00 – 13:00 Break
13:00 – 15:00 Part B: Monolix Suite for Efficient PK/PD Modelling
Dr. Géraldine Ayral
VP Application, Lixoft Inc., Francebr>
15:.00 – 15:15 Assignment announcement and closing
The 2021 APN Symposium
Updated: Sept. 17, 2021
Topic
Time November 25 (Day 1) November 26 (Day 2)
08:15 - 08:45 Registration Registration
08:45 - 09:00 Opening Remark
APN Taiwan
09:00 - 10:00 Plenary Lecture 1
Professor Nick Holford, University of Auckland, New Zealand
Concentration Controlled Dosing – TDM is Dead! Long Live TCI!
Plenary Lecture 2
Dr. Shiew-Mei Huang, US FDA
10:00 - 10:30 Break 1 & e-Poster*
10:30 - 11:00 Dr. Chen-His Chou, National Cheng Kung University, Taiwan Dr. Ping Zhao, Gates Foundation
Establishing Quantitative Science Platforms to Support Global
Health Product Development
11:00 - 11:30 Dr. Takahiko Tanigawa
PPKPD for Drug Development General Incorporated Association, Japan
Dr. Jenny Yueh Ling Chien, Eli Lilly (US)
Pharmacometrics for COVID- Related Drug Development
11:30 - 12:00 Professor Akhmad Kharis Nugroho, Indonesia Dr. Muhammad Usman, Pakistan
12:00 - 13:00 Lunch & e-Poster*
13:00 - 13:30 Dr. Lai San Tham, Eli Lilly, Singapore
Expanded Doses of Dulaglutide: An Example of Model-Informed Drug Development (MIDD)
Plenary Lecture 3
Professor Kyungsoo Park, APN President, Korea
The Use of Real-World Data in Drug Development
13:30 - 14:00 Hsueh-Yuan (Luke) Chang, Boehringer Ingelheim, CT, USA
The Development of a Translational Cerebral PBPK Model for mAb Disposition
14:00 - 14:30 Dr. Jiexin (Jason) Deng, Pfizer, China
Population Longitudinal Analysis of Magnetic Resonance Imaging and Time to Climb Four Stairs (4SC) in Duchenne Muscular Dystrophy Patients receiving Domagrozumab
Dr. Surulivel Rajan Mallayasamy, India
14:30 - 15:00 Break 2 & e-Poster*
15:00 - 15:30 Dr. Dinh Hoa Vu, Vietnam National DI and ADR Center, Viet Nam
Dose Individualization of Vancomycin: from TDM to MIPD
Dr. Yunn-Fang Ho, National Taiwan University, Taiwan
Towards Precision Dosing in Oncology: Modeling of 5-Fluorouracil as an Example

15:30 - 16:30
(15 min per presentation)

Oral Presentation Graduate student, Pakistan Oral Presentation Dr. Kyemyung Park, MD, PhD (Postdoctoral fellow), Korea
An Optimal Dosage Regimen Design Scheme to Minimize Paclitaxel and Cisplatin Induced Myelosuppression in Non-small Cell Lung Cancer
Graduate student, Taiwan Saki Takahashi, School of Pharmacy, Nihon University, Japan
Classification Tree Analysis Based on Machine Learning for Predicting Linezolid-Induced Thrombocytopenia
Dr. Arun Prasath R, PhD candidate, Department of Pharmacy Practice, MCOPS, Manipal, MAHE, India
Generalizable Model Development for Tacrolimus in Adult Renal Transplant Recipients: Pharmacometric Simulations Approach
Dr. Saikumar Matcha, PhD candidate, Department of Pharmacy Practice, MCOPS, Manipal, MAHE, India
Predictive Performance of Population Pharmacokinetic Models of Amikacin in Neonates
Dr. Ziteng Wang, Singapore Dr. Sook Hui Chaw, Associate Professor, Department of Anaesthesiology, Faculty of Medicine, University of Malaya
Population Pharmacokinetics and dosing simulations of oxycodone in adult surgical patients with obesity
16:30 – 16:45 Closure of Day 1
Dr. Yunn-Fang Ho
16:45 – 17:00   Closing Remark
Professor Kyungsoo Park, APN Chair
*e-Poster: online platform, max. 50 posters (poster + presenter's 2-3 min oral introduction)
Pre-symposium Workshop (November 23~24)Programs to be finalized soon.
The 2021 APN Satellite Workshop
< Workshop 1 >
Title: Pharmacometric Modeling & Simulation with Pumas.jl
Instructor: Dr. Vijay Ivaturi
Dates: Nov 21-24, 2021
Time: 11am – 3pm Taiwan time (16 hrs in total)
< Workshop 2 >
Title: Disease Progress and Drug Action (By Invitation only)
Instructor: Dr. Nick Holford
Date: Nov 24, 2021
Time: 9am – 1pm Taiwan time (4 hrs)